David Briscoe is an Associate Professor at Harvard Medical School and Director of the Transplant Research Program at Boston Children’s Hospital. He is also an elected member of the National Physician-Scientist Honors Society, the American Society of Clinical Investigation (ASCI). Research in the Briscoe Laboratory focuses on intragraft mechanisms of allograft rejection, and specifically how lymphocytes and monocytes interact with the vascular endothelium in the course of cell-mediated immune inflammatory reactions. Ongoing research projects address questions about endogenous signaling within the vascular endothelial cell that both inhibit and promote inflammation and how angiogenesis is associated with chronic allograft rejection. The laboratory also has an interest in how VEGF functions in inflammation, and how VEGFR interactions and signals alter T cell activation responses. The ultimate goal of our research is to understand the complexity of chronic allograft rejection and to identify molecules and/or targets that have therapeutic potential to inhibit alloimmune-mediated graft injury.