The focus of the program is to perform basic research to further understand the molecular basis for chronic allograft rejection in children, the leading cause of graft failure following transplantation. Members of the Transplant Research Program study the alloimmune response, the cellular basis for immunomodulation and roles for new molecules, novel receptors and signaling pathways that are causative of disease after transplantation. The application of these discoveries clinically advance our approach to therapy and have high potential to limit complications following transplantation. Our overall goal is to transform clinical care through basic and translational research and discovery.