Dr. David M. Briscoe
List of Publications

Selected Original Articles

1. Briscoe DM, Yeung AC, Schoen FJ, Allred EN, Stavrakis G, Ganz P, Cotran RS and Pober JS. Predictive value of inducible endothelial cell adhesion molecule expression for acute rejection of human cardiac allografts. Transplantation,59:204-211, 1995.

2. Moulton KS, Dharnidharka VR, Hardin-Young J, Melder RJ, Jain RK and Briscoe DM. Angiogenesis in the hu-PBL-SCID model of human transplant rejection. Transplantation; 67:1626-31, 1999.

3. Denton MD, Geehan C, Alexander SI, Sayegh MH and Briscoe DM. Endothelial cells modify the costimulatory capacity of transmigrating leukocytes and promote CD28-mediated CD4+ T cell alloactivation. Journal of Experimental Medicine, 190: 555-66,1999.

4. Melter M, Reinders MEJ, Sho M, Pal S, Geehan C, Denton MD, Mukhopadhyay D and Briscoe DM. Ligation of CD40 induces the expression of vascular endothelial growth factor by endothelial cells and monocytes and promotes angiogenesis in vivo. Blood, 96:3801-3808, 2000

5. Melter M, Exeni A, Reinders MEJ, Fang JC, McMahon G, Ganz P, Hancock WW, and Briscoe DM. Expression Of The Chemokine Receptor CXCR3 and its ligand IP-10 During Human Cardiac Allograft Rejection. Circulation, 104: 2558-2564, 2001.

6. Reinders MEJ, Sho M, Robertson SW, Geehan CS and Briscoe DM. Proangiogenic function of CD40L-CD40 interactions. Journal of Immunology, 171, 1534-41, 2003.

7. Reinders MEJ, Sho M, Izawa A, Wang P, Mukhopadhyay D, Koss KE, Geehan CS Luster AD, Sayegh MH and Briscoe DM. Proinflammatory functions of vascular endothelial growth factor in alloimmunity. Journal of Clinical Investigation. 112:1655–1665, 2003.

8. Flaxenburg JA, Melter M, Lapchak PH, *Briscoe DM and Pal S. [*Co-Senior Author]. The CD40-induced signaling pathway in endothelial cells resulting in the over-expression of vascular endothelial growth factor (VEGF) involves Ras and PI 3K. Journal of Immunology, 172: 7503-7509, 2004.

9. Denton MD, Magee C, Melter M, Dharnidharka VR, Sayegh MH and Briscoe DM. TNP-470, an angiogenesis inhibitor attenuates the development of allograft vasculopathy. Transplantation, 78:1218-21, 2004.

10. Laxmanan S, Robertson SW, Wang E, Lau J, Briscoe DM* and Mukhopadhyay D*. [*Co-Senior Authors]. Vascular endothelial growth factor impairs the functional ability of dendritic cells through Id pathways. Biochem Biophys Res Comm, Jul 4;334(1):193-198, 2005

11. Boulday G, Haskova Z, Reinders ME, Pal S and Briscoe DM. Vascular Endothelial Growth Factor-Induced Signaling Pathways in Endothelial Cells That Mediate Overexpression of the Chemokine IFN-gamma-inducible Protein of 10 kDa In Vitro and In Vivo. Journal of Immunology, 176(5):3098-3107, 2006.

12. Phung TL, Ziv K, Dabydeen D, Riveros M, Perruzzi C, Eyiah-Mensah G, Sun J-F, Monahan-Early R, Shiojima I, Nagy JA, Lin MI, Walsh K, Dvorak AM, Briscoe DM*, Neeman M, Sessa WC, Dvorak HF, Benjamin LE.  Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell. Aug;10(2):159-70, 2006.

13. Haskova Z, Izawa A, Contreras AG, Flynn E, Boulday G and Briscoe DM. Organ specific differences in the function of MCP-1 and CXCR3 during cardiac and skin allograft rejection. Transplantation, Jun 27;83(12):1595-1601, 2007.

14. Dormond O, Madsen JC and Briscoe DM. The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells. Journal of Biological Chemistry, Aug 10;282(32):23679-86, 2007.

15. Dormond O, Contreras AG, Meijer E, Datta D, Flynn E, Pal S, and Briscoe DM. CD40-induced signaling in human endothelial cells results in mTORC2- and Akt-dependent expression of vascular endothelial growth factor in vitro and in vivo. Journal of Immunology, Dec 1;181(11):8088-95, 2008.

16. Basu A, Hoerning A, Datta D, Edelbauer M, Stack MP, Calzadilla K, Pal S and Briscoe, DM. Vascular endothelial growth factor mediated signaling in human CD45RO+ CD4+ T cells promotes Akt and Erk activation and costimulates IFNγ production. Cutting Edge: Journal of Immunology, Jan 15;184(2):545-9, 2010.

17. Edelbauer M, Datta D, Vos IH, Basu A, Stack M, Reinders ME, Sho M, Calzadilla K, Ganz P and Briscoe DM. Effect of vascular endothelial growth factor and its receptor KDR on the transendothelial migration and local trafficking of human T cells in vitro and in vivo. Blood, 116(11):1980-9, 2010.

18. Hoerning A, Koss K, Datta D, Boneschansker L, Jones CN, Wong IY, Irimia D, Calzadilla K, Benitez F, Hoyer PF, Harmon WE and Briscoe DM. Subsets of human CD4+ T regulatory cells express the peripheral homing receptor CXCR3. In Press, European Journal of Immunology, 2011

Selected Review Articles

2. Reinders MEJ, Laning JC, Paul LC, and Briscoe DM. The role of chemokines in transplant immunology. Transplantation Reviews 17, 87-95, 2003

3. Reinders ME, Rabelink TJ and Briscoe DM. Angiogenesis and Endothelial Cell Repair in Renal Disease and Allograft Rejection. J Am Society Nephrol, Apr 17 (4), 932-42, 2006.

4. Contreras AG and Briscoe DM. Every allograft needs a silver lining. Journal of Clinical Investigation. Dec;117(12):3645-8, 2007.