| The Briscoe Laboratory Staff and Fellows |
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David M.
Briscoe M.D. Dr. David M. Briscoe graduated from the Royal College of Surgeons in Ireland in 1982. He performed his initial residency training in General Medicine and Pediatrics in Ireland and at the University of Colorado Health Sciences Center in Denver Colorado. He trained in Vascular Biology in Dr. Jordan Pober’s Laboratory at the Brigham and Women’s Hospital and completed his renal fellowship at the Children’s Hospital Boston in 1991. Subsequently, he extended his post-doctoral research training in Vascular Biology under the mentorship of Dr. Ramzi Cotran. In 1993, Dr. Briscoe joined the Faculty at the Children’s Hospital, Boston and established his own research effort with the support and mentorship of Dr. Andrew Lichtman, Brigham and Women’s Hospital. Dr. Briscoe has authored over 60 original publications and review articles. He serves on several advisory committee’s pertaining to transplantation and he is a member and past Councilor of the American Society of Transplantation (AST). In addition, he is a member of the National Physician-Scientist Honors Society, the American Society of Clinical Investigation (ASCI). Dr. Briscoe has received several awards for his research activities including the Basic Science Award of the AST. He served as Executive Program Chair for the American Transplant Congress (ATC) annual meeting 2002-2003, and as the Committee Chair for the American Society of Nephrology 2003 annual meeting (representing immunology and transplantation). He continues to participate in several national organizations and committees in an effort to promote research in transplantation medicine. Dr. Briscoe’s research effort focus's on an understanding of mechanisms by which lymphocytes and monocytes interact with the vascular endothelium in cell-mediated immune inflammatory reactions and allograft rejection. The vascular endothelium represents a unique interface between the recipient blood and the donor graft; ongoing studies test the possibility that the endothelial cell has the capacity to promote or/and inhibit inflammation and the rejection process. Most important contributions made by the Briscoe laboratory include: 1) The original descriptions of the expression of endothelial cell adhesion molecules and chemokines in human allografts, and publications on their mechanistic (and diagnostic) roles in acute and chronic rejection. 2) Studies defining a mechanism whereby the graft endothelium may alter the phenotype of T cells for responsiveness to intragraft cytokines; and a regulatory function of graft endothelial cells in the direct and the indirect pathways of allorecognition. 3) Studies demonstrating that alloimmune inflammation is associated with angiogenesis, and that CD40L-CD40 signaling mediates the expression of Vascular Endothelial Growth Factor (VEGF) ; and 4) that VEGF has potent proinflammatory properties and mediates lymphocyte trafficking in vitro and in vivo into sites of inflammation. Many of Dr. Briscoe’s trainees have received National Awards for their work including NRSA’s and K awards from the National Institutes of Health, as well as Faculty Career Development Awards from several societies including the AST, the American Heart Association and the National Kidney Foundation. |
| Laboratory
Assistants |
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Evelyn
Flynn, BS, MA Evelyn received a M.A. degree in biology from Boston University in 1990. She has worked in several research areas at Children’s Hospital Boston over the past 15 years and has a special interest in vascular biology and orthopedic research. She specializes in immunohistochemistry and electron microscopy and is a co-author on more than fifty publications. Evelyn is an experienced senior technologist in the laboratory, and enjoys working with fellows in teaching general laboratory techniques as well as histology/immunohistochemistry. |
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Megan McGourty, BS Megan received her Bachelor's degree in Biology from Bridgewater State University in 2010. She joined the Briscoe Laboratory as a research technician to learn and develop expertise in basic immunology and endothelial cell biology. She is interested in cell culture and molecular biology techniques, as well as the generation and maintenance of transgenic animals. Megan interacts with all fellows on a daily basis and is involved in the maintenance laboratory protocols. Megan is also involved in the processing of human blood samples from patients involved in multicenter CTOT studies that are ongoing in the laboratory. |
| Research Fellows |
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Leo Boneschansker Leo is a medical student from the University of Groningen, Holland, and is persuing a M.D. Ph.D. thesis as a collaboration with the Briscoe Laboratory. He is interested in mechanisms of renal inflammation, and is using microfluidics as a novel tool for the analysis of T cell migration at the single cell level. His studies involve interactions with the BioMEMS Resource Center and the Irimia laboratory at the Massachusetts General Hospital. Leo wishes to focus his studies on novel receptor ligand interactions that have potential as anti-inflammatory therapeutics. |
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Sarah Bruneau, Ph.D. Sarah received her Ph.D. from University of Nantes in France. During her predoctoral training, she studied an immunological mechanism underlying Focal and Segmental Glomerulosclerosis and its recurrence following kidney transplantation. She joined Dr. Briscoe's laboratory, where she plans to develop her interest in vascular immunology and skills in the analysis of cell signaling pathways and in molecular biology analyses. Her project will define regulators of mTOR-mediated signaling pathways and proinflammatory responses in endothelial cells. |
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Kevin Daly, M.D. Kevin completed his undergraduate training at Harvard College, where he worked for several years in a nationally recognized research laboratory studying the RAG-1 and RAG-2 proteins. He subsequently graduated in Medicine from Columbia University and completed his Pediatric Residency in New York prior to joining the Department of Cardiology at Children's Hospital Boston. He is currently Junior Faculty in the Cardiology Department and is pursuing further training in Pediatric Heart Failure and Transplantation. His long term career goal is in translation research. He joined Dr. Briscoe's laboratory where he is developing and validating biomarker profiles and imaging tools that have potential to aid in the diagnosis of chronic rejection in heart transplant recipients. |
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Craig Woda M.D., Ph.D. Craig is a Pediatric Nephrology Fellow within the Division of Nephrology at Children's Hospital Boston. He joined Dr. Briscoe's laboratory to initiate a research project on roles for the Akt/mTOR/HIF signaling pathway in endothelial cell activation, and how these intracellular signals function in the progression of chronic allograft rejection. Dr. Woda received his bachelor's degree in Physiology from Cornell University, and a Masters and a PhD degree in Physiology from Georgetown University. He subsequently trained as a post-doctoral researcher and as junior faculty in Renal Physiology at Mount Sinai School of Medicine in New York, NY prior to enrolling in the Albert Einstein College of Medicine. He completed his Pediatric Residency at Hasbro Children's Hospital/Brown Medical School in Rhode Island prior to joining the fellowship program at Children's Hospital Boston. |
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| 2011 | 2010 |
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| 2008 | 2006 |
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| 2003 | 2001 |
| Past Research Associates/Mentored Faculty |
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| Soumitro Pal Ph.D. 2001-2009 Current Position: Assistant Professor in Pediatrics Harvard Medical School Children's Hospital Boston |
Papia Banerjee, Ph.D. 2009-2010 Current Position: Research Associate, Research Operations Supervisor, Dana Farber Cancer Institute, Boston, Mass. |
| Past Research Fellows |
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Michelle Baum, M.D. 1994-1995 Assistant Professor of Pediatrics, Harvard Medical School, Children’s Hospital Boston, Boston, Massachusetts Ross Reul, M.D. 1995-1997 Assistant Professor in Surgery, Texas Heart Institute, Houston, Texas Stephen Alexander, M.D. 1995-1998 Assistant Professor, Children's Hospital, Sydney, Australia Vikas Dharnidharka, M.D. 1996-1998 Assistant Professor, University of Gainsville, Florida Mark Denton, M.D. 1996-1999 Consultant Nephrologist, Plymouth Hospitals, England Peter Shaw, M.D. 1998-2000 Deceased Andrea Exeni, M.D. 1998-2000 Michael
Melter, M.D. 1998-2000
Masayuki Sho, M.D., Ph.D. 1999- 2002 |
Ingrid Vos, Ph.D. 2000-2002 Stefan
Kiessling, M.D. 2002-2004 Jesse Flaxenburg, M.D. 2002-2005 Atsushi Izawa, M.D., Ph.D. 2002-2005 Zdenka Haskova, M.D., Ph.D. 2003-2005 Gwen Boulday, Ph.D. 2002-2006 Olivier Dormond, M.D., Ph.D. 2003-2007 |
Monika Edelbauer, M.D. 2006-2008 Alan Contreras, M.D. 2003-2008 Andre Hoerning, M.D. 2006-2008 Xiao Wu, M.D. Ph.D. 2006-2010 Aninda Basu, Ph.D. 2005-2009 Research Scientist, Beth Israel Deaconess Medical Center, Instructor in Medicine, Harvard Medical School Maria Stack, MB
2008-2010 Gearoid McMahon, M.D.
2008-2010 Tatsuichiro Seto, M.D., Ph.D.
2008-2011 |
| Past Laboratory Assistants |
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| Christopher Geehan J.D. 1996-2007 Chris served as the Briscoe Laboratory Manager and as the Manager of the newly formed Pediatric Transplantation Research Laboratories from 1996-2007. During this time, Chris attended Law School and passed the Massachussetts Bar in 2006. He currently works in the Intellectual Property Office of Children’s Hospital Boston as a member of their Legal team. |
Katiana Calzadilla BS, MS 2006-2011 Katiana served as a technician and as Laboratory Manager from 2006-2011. During this time, she performed a Masters Thesis in Biotechnology at the Harvard Extension School, and was awarded a Masters in Liberal Arts in Extension Studies from Harvard University in 2011. She left the laboratory to join Pharma and develop her career in Clinical Studies. |
| Kerrith Koss BS 2001-2003 Kerrith served as a technician in the laboratory from 2001-2003. She left the laboratory to re-enter University as a graduate student in 2004. |
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| Past Students
Thesis Students |
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| Marlies Reinders Mentored Ph.D. Thesis, University of Leiden, Holland |
Esther Meijer 2006-2007 Mentored M.D. Thesis University of Groningen, Holland |
| Summer Students |
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Gearoid McMahon 1998 Jeanette Reiners 2000 |
William Wong 1999-2004 Matthew Sheehan 2009 |